Interleukin-5

IL5
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	3VA2, 1HUL, 3QT2
Pengidentifikasi
Alias	IL5, EDF, IL-5, TRF, interleukin 5
ID eksternal	OMIM: 147850 MGI: 96557 HomoloGene: 679 GeneCards: IL5
Lokasi gen (Tikus)
Kr.	Kromosom 11 (tikus)
Akhir	53,615,933 bp
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• interleukin-5 receptor binding; • GO:0001948, GO:0016582 Ikatan protein plasma; • growth factor activity; • protein tyrosine kinase activity; • cytokine activity;
Komponen seluler	• extracellular region; • intracellular anatomical structure; • extracellular space;
Proses biologis	• positive regulation of DNA-binding transcription factor activity; • positive regulation of podosome assembly; • MAPK cascade; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 respons imun; • positive regulation of cell population proliferation; • positive regulation of eosinophil differentiation; • positive regulation of peptidyl-tyrosine phosphorylation; • inflammatory response; • positive regulation of receptor signaling pathway via JAK-STAT; • peptidyl-tyrosine phosphorylation; • positive regulation of B cell proliferation; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway;
	Sumber:Amigo / QuickGO
Ortolog
	3567
	16191
	ENSG00000113525
	ENSMUSG00000036117
	P05113
	P04401
	NM_000879
	NM_010558
	NP_000870
	NP_034688
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Interleukin-5, IL-5 (bahasa Inggris: eosinophil colony-stimulating factor, EDF, TRF) adalah sitokina sekresi sel T_H^[4] yang berperan dalam perkembangan dan diferensiasi sel B dan eosinofil.^[5]

Peningkatan rasio IL-5 dilaporkan terkait dengan asma dan sindrom hipereosinofilik,^[5] seperti eosinofilia.^[6] Tingginya rasio IL-5 juga ditemukan pada penderita penyakit Graves dan tiroiditis Hashimoto.^[7]

Referensi

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036117 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ (Inggris) "Naive helper T cells from BCG-vaccinated volunteers produce IFN-gamma and IL-5 to mycobacterial antigen-pulsed dendritic cells". Department of Immunology and Infectious Biology, University of Lodz; Kowalewicz-Kulbat M, Kaźmierczak D, Donevski S, Biet F, Pestel J, Rudnicka W. Diakses tanggal 2010-06-08.
^ ^a ^b (Inggris) "1: IL5 interleukin 5 (colony-stimulating factor, eosinophil) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-06-08.
^ (Inggris) "TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas". Department of Pathology, CHU of Liège, University of Liège; Thielen C, Radermacher V, Trimeche M, Roufosse F, Goldman M, Boniver J, de Leval L. Diakses tanggal 2010-06-08.
^ (Inggris) "The role of T-lymphocyte subsets and interleukin-5 blood levels among Indian subjects with autoimmune thyroid disease". Defence Bio-engineering and Electromedical Laboratory; Gopalakrishnan S, Sen S, Adhikari JS, Chugh PK, Sekhri T, Rajan S. Diakses tanggal 2010-06-08.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000036117 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] (Inggris) "Naive helper T cells from BCG-vaccinated volunteers produce IFN-gamma and IL-5 to mycobacterial antigen-pulsed dendritic cells". Department of Immunology and Infectious Biology, University of Lodz; Kowalewicz-Kulbat M, Kaźmierczak D, Donevski S, Biet F, Pestel J, Rudnicka W. Diakses tanggal 2010-06-08.

[entrez_3567-5] (Inggris) "1: IL5 interleukin 5 (colony-stimulating factor, eosinophil) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-06-08.

[6] (Inggris) "TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas". Department of Pathology, CHU of Liège, University of Liège; Thielen C, Radermacher V, Trimeche M, Roufosse F, Goldman M, Boniver J, de Leval L. Diakses tanggal 2010-06-08.

[7] (Inggris) "The role of T-lymphocyte subsets and interleukin-5 blood levels among Indian subjects with autoimmune thyroid disease". Defence Bio-engineering and Electromedical Laboratory; Gopalakrishnan S, Sen S, Adhikari JS, Chugh PK, Sekhri T, Rajan S. Diakses tanggal 2010-06-08.

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