CD44

CD44
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	1POZ, 1UUH, 2I83, 4PZ3, 4PZ4
Pengidentifikasi
Alias	CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 molecule (Indian blood group)
ID eksternal	OMIM: 107269 MGI: 88338 HomoloGene: 508 GeneCards: CD44
Lokasi gen (Manusia)
Kr.	Kromosom 11 (manusia)
Akhir	35,232,402 bp
Lokasi gen (Tikus)
Kr.	Kromosom 2 (tikus)
Akhir	102,732,010 bp
Pola ekspresi RNA
	; ; ; ;
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• collagen binding; • GO:0001948, GO:0016582 Ikatan protein plasma; • hyaluronic acid binding; • GO:0016518 cytokine receptor activity; • transmembrane signaling receptor activity;
Komponen seluler	• komponen integral membran; • badan Golgi; • macrophage migration inhibitory factor receptor complex; • membran; • focal adhesion; • Membran sel; • integral component of plasma membrane; • cell surface; • extracellular exosome; • sitosol; • secretory granule membrane; • membran plasma apikal; • lamellipodium membrane; • cell projection; • microvillus; • membran plasma basolateral;
Proses biologis	• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • monocyte aggregation; • positive regulation of heterotypic cell-cell adhesion; • hyaluronan catabolic process; • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • interferon-gamma-mediated signaling pathway; • extracellular matrix disassembly; • extracellular matrix organization; • negative regulation of apoptotic process; • cellular response to fibroblast growth factor stimulus; • positive regulation of peptidyl-serine phosphorylation; • cartilage development; • Adhesi sel; • negative regulation of DNA damage response, signal transduction by p53 class mediator; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of peptidyl-tyrosine phosphorylation; • cell-matrix adhesion; • positive regulation of monocyte aggregation; • leukocyte migration; • neutrophil degranulation; • wound healing, spreading of cells; • regulation of lamellipodium morphogenesis; • cell-cell adhesion; • inflammatory response; • Migrasi sel; • T cell activation; • positive regulation of kinase activity;
	Sumber:Amigo / QuickGO
Ortolog
	960
	12505
	ENSG00000026508
	ENSMUSG00000005087
	P16070
	P15379
NM_000610; NM_001001389; NM_001001390; NM_001001391; NM_001001392;
	NM_001202555; NM_001202556; NM_001202557
NM_001039150; NM_001039151; NM_001177785; NM_001177786; NM_001177787;
	NM_009851
NP_000601; NP_001001389; NP_001001390; NP_001001391; NP_001001392;
	NP_001189484; NP_001189485; NP_001189486
NP_001034239; NP_001034240; NP_001171256; NP_001171257; NP_001171258;
	NP_033981
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

CD44 adalah ekspresi gen berupa glikoprotein transmembran yang banyak mengalami variasi proteolitik.^[5] Isoform berupa CD44v banyak terdapat pada sel sekretori di sekitar kelenjar prostat, sedangkan ekspresi CD44s ditemukan pada seluruh jenis sel epitelial. Terganggunya ekspresi CD44 akan memungkinkan pertumbuhan tumor dan invasinya menjadi kanker.

Pada kanker prostat, hormon kalsitonin berperan sebagai faktor pertumbuhan parakrin yang menginduksi ekspresi varian CD44 yaitu CD44v7-10 melalui lintasan protein kinase A dan p38. CD44v7-10 memiliki daya cerap lebih besar terhadap fibronektin daripada senyawa hialuronan yang biasa dicerapnya,^[6] dan mengaktivasi lintasan MAPK.

Rujukan

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000026508 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005087 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ (Inggris) "MAP kinase pathways and calcitonin influence CD44 alternate isoform expression in prostate cancer cells". Department of Pathology, Anschutz Medical Campus, University of Colorado Denver; Eric W Robbins, Emily A Travanty, Kui Yang, dan Kenneth A Iczkowski. Diakses tanggal 2011-07-07.
^ (Inggris) "The predominant CD44 splice variant in prostate cancer binds fibronectin, and calcitonin stimulates its expression". Department of Pathology, The University of Florida, Veterans Administration Medical Center; Iczkowski KA, Omara-Opyene AL, Shah GV. Diakses tanggal 2011-07-07.

Artikel bertopik biokimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000026508 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005087 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] (Inggris) "MAP kinase pathways and calcitonin influence CD44 alternate isoform expression in prostate cancer cells". Department of Pathology, Anschutz Medical Campus, University of Colorado Denver; Eric W Robbins, Emily A Travanty, Kui Yang, dan Kenneth A Iczkowski. Diakses tanggal 2011-07-07.

[6] (Inggris) "The predominant CD44 splice variant in prostate cancer binds fibronectin, and calcitonin stimulates its expression". Department of Pathology, The University of Florida, Veterans Administration Medical Center; Iczkowski KA, Omara-Opyene AL, Shah GV. Diakses tanggal 2011-07-07.

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