Aromatase

Aromatase, juga disebutestrogen synthetase atau estrogen synthase, adalah sebuah enzim yang bertanggung jawab untuk langkah penting dalam biosintesis dari estrogen. Enzim tersebut berkode CYP19A1, sebuah anggopta dari keluarga besar sitokrome P450 (EC 1.14.14.1), yang bersifat monooksigenase yang memicu banyak reaksi yang terjadi pada steroidogenesis. Biasanya, aromatase bertanggung jawab untuk aromatisasi androgen menjadi estrogen.

CYP19A1
Struktur yang tersedia PDB Pencarian Ortolog: PDBe RCSB Daftar kode id PDB 3EQM, 3S79, 3S7S, 4GL5, 4GL7, 4KQ8
Pengidentifikasi
Alias	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM, cytochrome P450 family 19 subfamily A member 1
ID eksternal	OMIM: 107910 MGI: 88587 HomoloGene: 30955 GeneCards: CYP19A1
Lokasi gen (Tikus) Kr. Kromosom 9 (tikus) Pita 9 A5.3|9 29.49 cM Awal 54,073,221 bp Akhir 54,175,394 bp
Pola ekspresi RNA Referensi data ekspresi selengkapnya
Ontologi gen Fungsi molekuler • iron ion binding • oxygen binding • metal ion binding • monooxygenase activity • heme binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • electron transfer activity • oxidoreductase activity • aromatase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • steroid hydroxylase activity Komponen seluler • endoplasmic reticulum membrane • Retikulum endoplasma • membran • komponen integral membran Proses biologis • estrogen biosynthetic process • androgen metabolic process • negative regulation of chronic inflammatory response • prostate gland growth • sterol metabolic process • negative regulation of macrophage chemotaxis • steroid biosynthetic process • female gonad development • female genitalia development • perkembangan payudara • uterus development • testosterone biosynthetic process • androgen catabolic process • positive regulation of estradiol secretion • Rantai transpor elektron Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	1588	13075
Ensembl	ENSG00000137869	ENSMUSG00000032274
UniProt	P11511	P28649
RefSeq (mRNA)	NM_000103 NM_001347248 NM_001347249 NM_001347250 NM_001347251 NM_001347252 NM_001347253 NM_001347254 NM_001347255 NM_001347256 NM_031226	NM_007810 NM_001348171 NM_001348172 NM_001348173
RefSeq (protein)	NP_000094 NP_001334177 NP_001334178 NP_001334179 NP_001334180 NP_001334181 NP_001334182 NP_001334183 NP_001334184 NP_001334185 NP_112503	NP_001335100 NP_001335101 NP_001335102 NP_031836
Lokasi (UCSC)	n/a	Chr 9: 54.07 – 54.18 Mb
Pencarian PubMed
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

Bacaan tambahan

• Attar E, Bulun SE (May 2006). "Aromatase inhibitors: the next generation of therapeutics for endometriosis?". Fertility and Sterility. 85 (5): 1307–18. doi:10.1016/j.fertnstert.2005.09.064. PMID 16647373. 
• Chen S (August 1998). "Aromatase and breast cancer". Frontiers in Bioscience. 3 (4): d922–33. doi:10.2741/A333. PMID 9696881. 
• Strobel HW, Thompson CM, Antonovic L (June 2001). "Cytochromes P450 in brain: function and significance". Current Drug Metabolism. 2 (2): 199–214. doi:10.2174/1389200013338577. PMID 11469726. 
• Simpson ER, Clyne C, Rubin G, Boon WC, Robertson K, Britt K, Speed C, Jones M (2002). "Aromatase--a brief overview". Annual Review of Physiology. 64: 93–127. doi:10.1146/annurev.physiol.64.081601.142703. PMID 11826265. 
• Bulun SE, Yang S, Fang Z, Gurates B, Tamura M, Zhou J, Sebastian S (December 2001). "Role of aromatase in endometrial disease". The Journal of Steroid Biochemistry and Molecular Biology. 79 (1–5): 19–25. doi:10.1016/S0960-0760(01)00134-0. PMID 11850203. 
• Balthazart J, Baillien M, Ball GF (December 2001). "Phosphorylation processes mediate rapid changes of brain aromatase activity". The Journal of Steroid Biochemistry and Molecular Biology. 79 (1–5): 261–77. doi:10.1016/S0960-0760(01)00143-1. PMID 11850233. 
• Richards JA, Petrel TA, Brueggemeier RW (February 2002). "Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells". The Journal of Steroid Biochemistry and Molecular Biology. 80 (2): 203–12. doi:10.1016/S0960-0760(01)00187-X. PMID 11897504. 
• Balthazart J, Baillien M, Ball GF (May 2002). "Interactions between aromatase (estrogen synthase) and dopamine in the control of male sexual behavior in quail". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 132 (1): 37–55. doi:10.1016/S1096-4959(01)00531-0. PMID 11997208. 
• Meinhardt U, Mullis PE (2002). "The aromatase cytochrome P-450 and its clinical impact". Hormone Research. 57 (5–6): 145–52. doi:10.1159/000058374. PMID 12053085. 
• Carreau S, Bourguiba S, Lambard S, Galeraud-Denis I, Genissel C, Levallet J (July 2002). "Reproductive system: aromatase and estrogens". Molecular and Cellular Endocrinology. 193 (1–2): 137–43. doi:10.1016/S0303-7207(02)00107-7. PMID 12161013. 
• Meinhardt U, Mullis PE (August 2002). "The essential role of the aromatase/p450arom". Seminars in Reproductive Medicine. 20 (3): 277–84. doi:10.1055/s-2002-35374. PMID 12428207. 
• Carreau S, Bourguiba S, Lambard S, Galeraud-Denis I (2003). "[Testicular aromatase]". Journal de la Société de Biologie. 196 (3): 241–4. doi:10.1051/jbio/2002196030241. PMID 12462076. 
• Carani C, Fabbi M, Zirilli L, Sgarbi I (2003). "[Estrogen resistance and aromatase deficiency in humans]". Journal de la Société de Biologie. 196 (3): 245–8. doi:10.1051/jbio/2002196030245. PMID 12462077. 
• Kragie L (August 2002). "Aromatase in primate pregnancy: a review". Endocrine Research. 28 (3): 121–8. doi:10.1081/ERC-120015041. PMID 12489562. 
• Simpson ER (July 2000). "Biology of aromatase in the mammary gland". Journal of Mammary Gland Biology and Neoplasia. 5 (3): 251–8. doi:10.1023/A:1009590626450. PMID 14973387. 
• Bulun SE, Takayama K, Suzuki T, Sasano H, Yilmaz B, Sebastian S (February 2004). "Organization of the human aromatase p450 (CYP19) gene". Seminars in Reproductive Medicine. 22 (1): 5–9. doi:10.1055/s-2004-823022. PMID 15083376. 
• Simpson ER (February 2004). "Aromatase: biologic relevance of tissue-specific expression". Seminars in Reproductive Medicine. 22 (1): 11–23. doi:10.1055/s-2004-823023. PMID 15083377. 
• Bulun SE, Fang Z, Imir G, Gurates B, Tamura M, Yilmaz B, Langoi D, Amin S, Yang S, Deb S (February 2004). "Aromatase and endometriosis". Seminars in Reproductive Medicine. 22 (1): 45–50. doi:10.1055/s-2004-823026. PMID 15083380. 
• Shozu M, Murakami K, Inoue M (February 2004). "Aromatase and leiomyoma of the uterus". Seminars in Reproductive Medicine. 22 (1): 51–60. doi:10.1055/s-2004-823027. PMID 15083381. 
• Chen S, Ye J, Kijima I, Kinoshita Y, Zhou D (May 2005). "Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue". The Journal of Steroid Biochemistry and Molecular Biology. 95 (1–5): 17–23. doi:10.1016/j.jsbmb.2005.04.002. PMID 15955695. 
• Lambard S, Silandre D, Delalande C, Denis-Galeraud I, Bourguiba S, Carreau S (May 2005). "Aromatase in testis: expression and role in male reproduction". The Journal of Steroid Biochemistry and Molecular Biology. 95 (1–5): 63–9. doi:10.1016/j.jsbmb.2005.04.020. PMID 16019206. 
• Bulun SE, Imir G, Utsunomiya H, Thung S, Gurates B, Tamura M, Lin Z (May 2005). "Aromatase in endometriosis and uterine leiomyomata". The Journal of Steroid Biochemistry and Molecular Biology. 95 (1–5): 57–62. doi:10.1016/j.jsbmb.2005.04.012. PMID 16024248. 
• Lambard S, Carreau S (October 2005). "Aromatase and oestrogens in human male germ cells". International Journal of Andrology. 28 (5): 254–9. doi:10.1111/j.1365-2605.2005.00546.x . PMID 16128984. 
• Ellem SJ, Risbridger GP (March 2006). "Aromatase and prostate cancer". Minerva Endocrinologica. 31 (1): 1–12. PMID 16498360. 
• Brueggemeier RW, Díaz-Cruz ES (March 2006). "Relationship between aromatase and cyclooxygenases in breast cancer: potential for new therapeutic approaches". Minerva Endocrinologica. 31 (1): 13–26. PMID 16498361. 
• Jongen VH, Hollema H, Van Der Zee AG, Heineman MJ (March 2006). "Aromatase in the context of breast and endometrial cancer. A review". Minerva Endocrinologica. 31 (1): 47–60. PMID 16498363. 
• Hiltunen M, Iivonen S, Soininen H (March 2006). "Aromatase enzyme and Alzheimer's disease". Minerva Endocrinologica. 31 (1): 61–73. PMID 16498364. 

Pranala luar

• "U.S. study of gay sheep may shed light on sexuality", via WikiNews, 15 August 2005.
• Lokasi genom CYP19A1 manusia dan halaman rincian gen CYP19A1 dalam UCSC Genome Browser.
• Templat:PDBe-KB2